Major trends in the manifestations and treatment of rheumatoid arthritis in a multiethnic cohort in Singapore
Identifieur interne : 001381 ( Main/Exploration ); précédent : 001380; suivant : 001382Major trends in the manifestations and treatment of rheumatoid arthritis in a multiethnic cohort in Singapore
Auteurs : Ee Tzun Koh [Singapour] ; Justina Wei Lynn Tan [Singapour] ; Bernard Yu-Hor Thong [Singapour] ; Cheng Lay Teh [Singapour] ; Tsui Yee Lian [Singapour] ; Weng Giap Law [Singapour] ; Arul Earnest [Singapour] ; Kok Ooi Kong [Singapour] ; Tang Ching Lau [Singapour] ; Yew Kuang Cheng [Singapour] ; Hwee Siew Howe [Singapour] ; Wern Hui Yong [Singapour] ; Faith Li-Ann Chia [Singapour] ; Hiok Hee Chng [Singapour] ; Khai Pang Leong [Singapour]Source :
- Rheumatology International [ 0172-8172 ] ; 2013-07-01.
Descripteurs français
- Wicri :
- topic : épidémiologie, Qualité de la vie.
English descriptors
- KwdEn :
Abstract
Abstract: We analyzed the epidemiological changes of rheumatoid arthritis (RA) over three decades using patients from a single center in Singapore. All patients who fulfill the 1987 American College of Rheumatology criteria for RA were invited to enroll in a prospective disease registry. We analyzed the patient demographics, disease manifestation, management and patient-reported outcomes, including quality of life (QoL), in the three categories according to the year of disease onset: before 1989 (group I), 1990–1999 (group II) and after 2000 (group III). There were 1,153 patients with 231, 532 and 390 in groups I, II and III, respectively. The mean disease durations were 25, 12 and 4.8 years, respectively. The majority was female (84.1 %) and Chinese (76.6 %) with no socio-demographic differences across the three periods. The age of onset rises and the prevalence of rheumatoid factor falls with the proximity of disease onset. Patients with most recent disease onset had the earliest access to the rheumatologist. They also had the highest tender and swollen joint counts, lowest deformed joint count and highest remission rate. Patients in group I report better mental and emotional QoL though many developed marked disability. We have documented changes of the manifestations of RA that are dependent and independent of improved treatment. Significant differences in accessibility to the rheumatologist, RA activity, functional capacity, quality of life and comorbidities were seen in subsequent cohorts due to treatment evolution and more efficient healthcare delivery.
Url:
DOI: 10.1007/s00296-012-2602-2
Affiliations:
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type="eISSN">1437-160X</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="2013-07-01">2013-07-01</date><biblScope unit="volume">33</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1693">1693</biblScope><biblScope unit="page" to="1703">1703</biblScope></imprint><idno type="ISSN">0172-8172</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0172-8172</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Asian</term><term>Epidemiology</term><term>Functional status</term><term>Outcome measures</term><term>Quality of life</term><term>Rheumatoid arthritis</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>épidémiologie</term><term>Qualité de la vie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: We analyzed the epidemiological changes of rheumatoid arthritis (RA) over three decades using patients from a single center in Singapore. All patients who fulfill the 1987 American College of Rheumatology criteria for RA were invited to enroll in a prospective disease registry. We analyzed the patient demographics, disease manifestation, management and patient-reported outcomes, including quality of life (QoL), in the three categories according to the year of disease onset: before 1989 (group I), 1990–1999 (group II) and after 2000 (group III). There were 1,153 patients with 231, 532 and 390 in groups I, II and III, respectively. The mean disease durations were 25, 12 and 4.8 years, respectively. The majority was female (84.1 %) and Chinese (76.6 %) with no socio-demographic differences across the three periods. The age of onset rises and the prevalence of rheumatoid factor falls with the proximity of disease onset. Patients with most recent disease onset had the earliest access to the rheumatologist. They also had the highest tender and swollen joint counts, lowest deformed joint count and highest remission rate. Patients in group I report better mental and emotional QoL though many developed marked disability. We have documented changes of the manifestations of RA that are dependent and independent of improved treatment. Significant differences in accessibility to the rheumatologist, RA activity, functional capacity, quality of life and comorbidities were seen in subsequent cohorts due to treatment evolution and more efficient healthcare delivery.</div></front></TEI><affiliations><list><country><li>Singapour</li></country></list><tree><country name="Singapour"><noRegion><name sortKey="Koh, Ee Tzun" sort="Koh, Ee Tzun" uniqKey="Koh E" first="Ee Tzun" last="Koh">Ee Tzun Koh</name></noRegion><name sortKey="Cheng, Yew Kuang" sort="Cheng, Yew Kuang" uniqKey="Cheng Y" first="Yew Kuang" last="Cheng">Yew Kuang Cheng</name><name sortKey="Chia, Faith Li Ann" sort="Chia, Faith Li Ann" uniqKey="Chia F" first="Faith Li-Ann" last="Chia">Faith Li-Ann Chia</name><name sortKey="Chng, Hiok Hee" sort="Chng, Hiok Hee" uniqKey="Chng H" first="Hiok Hee" last="Chng">Hiok Hee Chng</name><name sortKey="Earnest, Arul" sort="Earnest, Arul" uniqKey="Earnest A" first="Arul" last="Earnest">Arul Earnest</name><name sortKey="Earnest, Arul" sort="Earnest, Arul" uniqKey="Earnest A" first="Arul" last="Earnest">Arul Earnest</name><name sortKey="Howe, Hwee Siew" sort="Howe, Hwee Siew" uniqKey="Howe H" first="Hwee Siew" last="Howe">Hwee Siew Howe</name><name sortKey="Kong, Kok Ooi" sort="Kong, Kok Ooi" uniqKey="Kong K" first="Kok Ooi" last="Kong">Kok Ooi Kong</name><name sortKey="Lau, Tang Ching" sort="Lau, Tang Ching" uniqKey="Lau T" first="Tang Ching" last="Lau">Tang Ching Lau</name><name sortKey="Law, Weng Giap" sort="Law, Weng Giap" uniqKey="Law W" first="Weng Giap" last="Law">Weng Giap Law</name><name sortKey="Leong, Khai Pang" sort="Leong, Khai Pang" uniqKey="Leong K" first="Khai Pang" last="Leong">Khai Pang Leong</name><name sortKey="Lian, Tsui Yee" sort="Lian, Tsui Yee" uniqKey="Lian T" first="Tsui Yee" last="Lian">Tsui Yee Lian</name><name sortKey="Tan, Justina Wei Lynn" sort="Tan, Justina Wei Lynn" uniqKey="Tan J" first="Justina Wei Lynn" last="Tan">Justina Wei Lynn Tan</name><name sortKey="Tan, Justina Wei Lynn" sort="Tan, Justina Wei Lynn" uniqKey="Tan J" first="Justina Wei Lynn" last="Tan">Justina Wei Lynn Tan</name><name sortKey="Teh, Cheng Lay" sort="Teh, Cheng Lay" uniqKey="Teh C" first="Cheng Lay" last="Teh">Cheng Lay Teh</name><name sortKey="Thong, Bernard Yu Hor" sort="Thong, Bernard Yu Hor" uniqKey="Thong B" first="Bernard Yu-Hor" last="Thong">Bernard Yu-Hor Thong</name><name sortKey="Yong, Wern Hui" sort="Yong, Wern Hui" uniqKey="Yong W" first="Wern Hui" last="Yong">Wern Hui Yong</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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